Experts say it will still take many months to know if this vaccine, or others also in research, will work.
The first person to get the jab on Monday was a 43-year-old mother-of-two from Seattle.
"This is an amazing opportunity for me to do something," Jennifer Haller told AP.
Scientists around the world are fast-tracking research.
And this first human trial, funded by the National Institutes of Health, sidesteps a check that would normally be conducted – making sure the vaccine can trigger an immune response in animals.
But the biotechnology company behind the work, Moderna Therapeutics, says the vaccine has been made using a tried and tested process.
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